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HIV-1 TAT VACCINES: SECOND GENERATION |
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| Tat + Env combination (code T2-alpha) |
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| T2-alpha is a vaccination regimen by which individual formulations of Tat and Env proteins will be administered in combination. |
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| The separate formulations contain, respectively, the biologically active Tat and a modified Env protein. |
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| Preclinical studies in monkeys indicate that the Tat/Env combination is safe and superior at inducing neutralizing antibodies and, at the same time, increases the breath of the immune-responses to the single components.
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| Based on these findings, the National AIDS Center is starting a phase I preventive study based on the association of Tat and Env proteins (ISS P-002 - click here). |
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