| |
HIV-1 TAT VACCINES: SECOND GENERATION |
|
|
| Tat + Env combinations (code T2-alpha) |
| |
| T2-alpha is a vaccination regimen by which individual formulations of Tat and Env proteins will be administered in combination. |
| |
| The separate formulations contain, respectively, Env and biologically-active Tat suspended in formulation buffer and stored at -80°C until administration. |
| |
| Preclinical studies in monkeys indicate that the Tat/Env combination is safe and superior at inducing neutralizing antibodies and, at the same time, increase the breathe of the immune-responses to the single components.
|
| |
| Based on these findings, the Italian Scientists are starting Phase I studies with candidate vaccines that combine Tat and Env. |
| |
